To get going, this file (index.html) includes some basic styles you can modify, play around with, or totally destroy to get going.
Once you've exhausted the fun in this document, you should check out:
Everything you need to know about using the framework.
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This is a twelve cell section in a grid-x. Each of these includes a div.callout element so you can see where the cell are - it's not required at all for the grid.